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The purpose of the study is usually to characterize the metabolites of EAM-2201 in human hepatocytes acquired in vitro and those in liver and urine specimens received in vivo from your autopsy of an EAM-2201 abuser.

Twelve metabolites of the artificial cannabinoid, EAM-2201, have been tentatively recognized in human hepatocytes in vitro, As well as in human liver and urine specimens in vivo for The 1st time. There was a distinct distinction in metabolism profile between the in vitro As well as in vivo benefits.

EAM-2201 was incubated with human hepatocytes for three h inside a CO2 incubator and also the metabolites of EAM-2201 were being created. The human liver specimen was homogenized as well as the metabolites ended up extracted. The urine specimen was hydrolyzed very first with β-glucuronidase as well as metabolites were extracted.

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